Exercise Diabetes Study

Active study and enrolling
Purpose of study
Exercise has been shown to prevent diabetes and is a proven treatment for metabolic imbalances that occur in people with diabetes. However, people with diabetes, metabolic syndrome, or “pre-diabetes”, often have poor exercise tolerance. Researchers at Washington University are trying to understand better how skeletal muscle activity effects diabetes risk.
Participants
If you are a healthy adult who is overweight, has mild high blood pressure, and high cholesterol or you have been told that you have “pre-diabetes” you might be able to participate in this research study.
Qualifications for participation
- You are between the ages of 18 and 65
- You do not currently use Tobacco (former smokers are eligible)
- You exercise fewer than 2 days per week for less than 15 minutes
- You do not have any major illness (such as: Diabetes, heart, kidney, lung, liver disease, cancer)
Study information
Washington University is conducting this study. The study includes a screening visit, lasting about 1 hour, to determine if you are eligible for the study. If you are eligible there are 2 brief phone visits, lasting about 15 to 30 minutes, to confirm that you are making no changes to your diet or exercise habits. The final clinic visit lasts about 4 to 6 hours but may be split into 2 visits depending upon scheduling availability.
The screening visit includes a review of your medical history and medications, blood drawing for routine tests (such as fasting blood sugar and cholesterol tests); measurement of height, weight and blood pressure, and discussion of exercise and eating habits.
If you continue to be eligible after screening at the final visit you will undergo:
- An Oral Glucose Tolerance Test (participant drinks a sweet drink and blood sugar is measured at time-points over a 2 ½ hour period)
- Bone Mineral Density Scan (DEXA) (30 minute test with participant lying on a table while machine scans body)
- Muscle Biopsy (participants will have an area on the thigh numbed with lidocaine and a small incision (less than 1cm) made to remove a tiny piece of muscle tissue (about 1/15th of an ounce) to be analyzed)
Compensation is $500 if all study visits and procedures are completed. The entire study is completed within 4 to 5 weeks.
I’m interested, where do I get more information?
Janet McGill, MD (314) 362-4331
Mary Jane Clifton (314) 362-8681
researchconnections@dom.wustl.edu
Investigator
Clay F. Semenkovich, MD