Exercise Diabetes Study

Exercise Diabetes Study

Active study and enrolling

Purpose of study

Exercise has been shown to prevent diabetes and is a proven treatment for metabolic imbalances that occur in people with diabetes.  However, people with diabetes, metabolic syndrome, or “pre-diabetes”, often have poor exercise tolerance.  Researchers at Washington University are trying to understand better how skeletal muscle activity effects diabetes risk.


If you are a healthy adult who is overweight, has mild high blood pressure, and high cholesterol or you have been told that you have “pre-diabetes” you might be able to participate in this research study.

Qualifications for participation

  1. You are between the ages of 18 and 65
  2. You do not currently use Tobacco (former smokers are eligible)
  3. You exercise fewer than 2 days per week for less than 15 minutes
  4. You do not have any major illness (such as: Diabetes, heart, kidney, lung, liver disease, cancer)

Study information

Washington University is conducting this study.  The study includes a screening visit, lasting about 1 hour, to determine if you are eligible for the study.  If you are eligible there are 2 brief phone visits, lasting about 15 to 30 minutes, to confirm that you are making no changes to your diet or exercise habits.  The final clinic visit lasts about 4 to 6 hours but may be split into 2 visits depending upon scheduling availability.

The screening visit includes a review of your medical history and medications, blood drawing for routine tests (such as fasting blood sugar and cholesterol tests); measurement of height, weight and blood pressure, and discussion of exercise and eating habits.

If you continue to be eligible after screening at the final visit you will undergo:

  • An Oral Glucose Tolerance Test (participant drinks a sweet drink and blood sugar is measured at time-points over a 2 ½ hour period)
  • Bone Mineral Density Scan (DEXA) (30 minute test with participant lying on a table while machine scans body)
  • Muscle Biopsy (participants will have an area on the thigh numbed with lidocaine and a small incision (less than 1cm) made to remove a tiny piece of muscle tissue (about 1/15th of an ounce) to be analyzed)

Compensation is $500 if all study visits and procedures are completed. The entire study is completed within 4 to 5 weeks.

I’m interested, where do I get more information?

Janet McGill, MD   (314) 362-4331

Mary Jane Clifton  (314) 362-8681



Clay F. Semenkovich, MD

ClinicalTrials.gov Identifier