Vitamin D, Insulin Resistance, and Cardiovascular Disease
Active study, but not enrolling
Title of study
Vitamin D, Insulin Resistance, and Cardiovascular Disease
Eligibility
Ages Eligible for Study 25 to 80 years
Genders Eligible for Study Both
Ethnic/Racial Eligible for Study Everything
Accepts Healthy Volunteers No
Inclusion criteria
- Type 2 diabetes
- 25 (OH) vitamin D levels < 25 ng/ml
- Not on insulin for diabetes treatment
- HbA1c 5.5% -9.5%
- Mild/moderately increased blood pressure (systolic 120-160, diastolic 80-100) off BP medications
Exclusion criteria
- Pregnancy
- Patients with systolic >160 or diastolic >100 mmHg
- High urine calcium or history of recurrent kidney stones
- Cardiovascular disease
- Stage 3 or worse chronic kidney disease
Purpose of study
In recent years, vitamin D has been shown not only to be important for bone and calcium metabolism but also for homeostasis of critical tissues involved in vascular disease in patients with diabetes. Epidemiological studies indicated the high prevalence of vitamin D deficiency among Type 2 DM patients and suggest an increased risk of cardiovascular disease and hypertension with low vitamin D levels. The objective of this proposal is to evaluate the effects of vitamin D replacement on blood pressure control and vascular disease in vitamin D deficient hypertensive patients with diabetes.
Primary outcome measures
Hypertension
Investigators
Principal investigator
Carlos Bernal-Mizrachi, MD
Co-investigator
Amy E. Riek, MD
Contact information
Phone
314-362-0934