Vitamin D, Insulin Resistance, and Cardiovascular Disease

Vitamin D and Cardiovascular Disease-760x507

Active study, but not enrolling

Title of study

Vitamin D, Insulin Resistance, and Cardiovascular Disease


Ages Eligible for Study 25 to 80 years
Genders Eligible for Study Both
Ethnic/Racial Eligible for Study Everything
Accepts Healthy Volunteers No

Inclusion criteria

  • Type 2 diabetes
  • 25 (OH) vitamin D levels < 25 ng/ml
  • Not on insulin for diabetes treatment
  • HbA1c 5.5% -9.5%
  • Mild/moderately increased blood pressure (systolic 120-160, diastolic 80-100) off BP medications

Exclusion criteria

  • Pregnancy
  • Patients with systolic >160 or diastolic >100 mmHg
  • High urine calcium or history of recurrent kidney stones
  • Cardiovascular disease
  • Stage 3 or worse chronic kidney disease

Purpose of study

In recent years, vitamin D has been shown not only to be important for bone and calcium metabolism but also for homeostasis of critical tissues involved in vascular disease in patients with diabetes. Epidemiological studies indicated the high prevalence of vitamin D deficiency among Type 2 DM patients and suggest an increased risk of cardiovascular disease and hypertension with low vitamin D levels. The objective of this proposal is to evaluate the effects of vitamin D replacement on blood pressure control and vascular disease in vitamin D deficient hypertensive patients with diabetes.

Primary outcome measures



Principal investigator

Carlos Bernal-Mizrachi, MD


Amy E. Riek, MD

Contact information



314-362-0934 Identifier