On March 16, Jeffrey R. Millman, PhD and collaborators had their research titled “Differential Function and Maturation of Human Stem Cell-Derived Islets After Transplantation,” published in issue 3 of “Stem Cells Translational Medicine.”
It is evident that cell replacement therapy is a potential treatment for patients with diabetes. One possible renewable source of replacement cells are stem-cell derived islets (SC-islets). This study offers a deeper evaluation of insulin-producing SC-islets by examining the effects of cell dose, transplantation strategy and diabetic state in immunocompromised mice.
Their findings demonstrate that “common transplantation parameters affect the function and maturation of SC-islets in mice.” Therefore, the linkage of transplantation parameters to SC-islet function and maturation, provide ideal mouse models for preclinical diabetes stem cell therapy research.