Haowei Song, PhD
Research Instructor in Medicine
Ph.D. Fudan University, Shanghai, P. R. China
Postdoctoral Training Washington University in St. Louis, St. Louis, MO
Dr. Song is interested in understanding molecular mechanisms that regulate insulin signaling and lipid metabolism in metabolic diseases, such as diabetes and metabolic syndrome, and in developing new techniques and approaches to study these processes. He employs a variety of techniques in his studies that include state of art mass spectrometric proteomics, lipidomics, and metabolomics analyses, in addition to traditional molecular biologic experiments, cell culture-based systems, and genetically altered mouse models. He also hopes to explore the implications of findings in these cell and animal models for human endocrinologic and metabolic disorders.
Molecular mechanisms underlying metabolism disorders
- Role of pancreatic islet Ca2+-independent phospholipase A2 (iPLA2β) in cardiolipin remodeling and mitochondrial function.
- Role of iPLA2β in macrophage apoptosis and atherosclerosis.
- Regulation of glucose signaling via protein posttranslational modification.
Development of novel techniques to study metabolic disorders:
- Developing bioinformatics tools for processing lipidomics (LipidQA) and metabolomics data sets.
- Developing devices for online blood sampling and metabolite extraction for metametabolomics (“fluxomics”) studies.