Xiaochao Wei was born in Tianjin, China. He attended Beijing Medical University in the program of Basic Medical Sciences from 1995, and graduated with a Bachelor of Science degree in 2000. He did his graduate studies at University of Rochester in the department of biochemistry from 2001, where he pursued his research in inflammatory bone disease under the direction of Dr. Regis O’Keefe, in the center for musculoskeletal research. He received a Master of Science degree in 2003 and a PhD in 2007. In 2007 he came to Dr. Clay Semenkovich’s laboratory in Washington University at St. Louis to study the physiology and pathology of lipid signaling in metabolism.
My current research is focused on the physiological function of fatty acid synthase (FAS) in endothelial cells. We found that: 1) Endothelial cell-specific FAS knockout (FASTie) mice are susceptible to low-dose LPS administration. 2) The plasma membrane localization of endothelial nitric oxide synthase (eNOS) is diminished in FASTie mice, which might cause the dysfunction of blood vessel. The mechanisms of mistargeting of eNOS and its relationship with the hypersensitive response to LPS are under investigation.