Tag: atherosclerosis

Stitham, Lodhi and colleagues reveal the mechanistic details of macrophage mTOR signaling in atherosclerosis

In June 2023, Jeremiah Stitham, MD, PhD; Irfan Lodhi, PhD and colleagues led by the corresponding author Babak Razani MD, PhD had their research article titled “Loss of Macrophage mTORC2 Drives Atherosclerosis via FoxO1 and IL-1β Signaling,” published by Circulation Research. “The mTOR (mechanistic target of rapamycin) pathway is a complex signaling cascade that regulates […]

Semenkovich publishes research on mechanisms to improve targeted atherosclerosis therapy 

On June 15, Clay F. Semenkovich, MD and collaborators had their research titled “Altered Peroxisome Proliferator-Activated Receptor Alpha Signaling in Variably Diseased Peripheral Arterial Segments,” published in “Frontiers in Cardiovascular Medicine.”  “Peripheral atherosclerosis that accumulates in the extracranial carotid and lower extremity arteries can lead to significant morbidity and mortality. However, atherosclerotic disease progression is […]