Crewe and Sabio share protocol for isolation of adipose tissue extracellular vesicles 

On April 20, Clair Crewe, PhD and Jessica M. Sabio had their protocol titled “Isolation of Adipose Tissue Extracellular Vesicles,” published in the book series “Thermogenic Fat: Methods in Molecular Biology.”  Between cells in tissue and circulation, you’ll find extracellular vesicles (EV). Which are produced by adipocytes and other adipose tissue (AT) cells and send […]

Crewe publishes research on how iron levels can control systemic metabolism 

In November, Clair Crewe, PhD and collaborators has their research titled “Adipose tissue macrophages exert systemic metabolic control by manipulating local iron concentrations,” published in “Nature Metabolism.”  The cellular compartmentalization and concentration of iron in biological processes is important and needs to be closely monitored and controlled. “Although iron overload can contribute to obesity-associated metabolic […]

Crewe publishes research on the effects of adipocyte mesenchymal transition on mammary tumors 

On September 13, 2022, Clair Crewe, PhD and colleagues had their work titled “Adipocyte mesenchymal transition contributes to mammary tumor progression,” published in “Cell Reports.”  “Obesity is associated with increased cancer incidence and progression.” There is a need for more research in understanding the mechanistic relationship between adiposity and cancer.  In the study, Crewe and […]