Protein palmitoylation helps to model the evolution of some forms of type 2 diabetes   

On February 7, Guifang Dong, PhD; Sangeeta Adak, PhD; Qiang Zhang, PhD; Chu Feng, MS; Li Yin, MD; Sarah Speck; Shuntaro Morikawa; Rie Asada, PhD; Fumihiko Urano, MD, PhD; Maria Remedi, PhD; Xiaochao Wei, PhD; Clay Semenkovich, MD; and collaborators had their work published in “Cell Metabolism.”  “Hyperinsulinemia often precedes type 2 diabetes,” and palmitoylation, […]

Zhang publishes research on the diagnosis and monitoring of onchocerciasis 

In January, Qiang Zhang, PhD and collaborators had their research titled “Direct Proteomic Detection and Prioritization of 19 Onchocerciasis Biomarker Candidates in Humans,” published in “Molecular and Cellular Proteomics.”  Onchocerca volculus is the causative agent of onchocerciasis. Which affects over 20 million people, causing severe dermatitis and ocular conditions, including blindness. As current treatments do […]

Semenkovich Lab and collaborators show the evolution of type 2 diabetes through APT1 deficiency 

On January 11, Semenkovich Lab and collaborators, had their research titled “Palmitoylation couples insulin hypersecretion with β cell failure in diabetes,” published in “Cell Metabolism.”  Hyperinsulinemia is known to often come before type 2 diabetes. In the study, they explain how acyl-protein thioesterase 1 (APT1) knockdown in nondiabetic islets causes insulin hypersecretion.  By using palmitoylation proteomics, their […]