Remedi and colleagues offer insight to insulin secretion disruption associated with KATP loss

On February 10, Maria S. Remedi, PhD and colleagues had their abstract titled “Hyperexcitability reduces TRPM5 in pancreatic β-cells: Insights into disruption of insulin secretion in chronically stimulated islets,” published in Biophysical Journal.  “Acute inhibition of ATP-sensitive K+ (KATP) channels in pancreatic β-cells result in depolarization, Ca2+ influx, and insulin secretion.” Throughout their research, the […]

Remedi and Nichols discuss glucokinase inhibition as an approach to diabetes treatment

On January 20, Maria S. Remedi, PhD and Colin G. Nichols, PhD had their perspective published in the American Diabetes Association’s diabetes journal, titled “Glucokinase Inhibition: A Novel Treatment for Diabetes?”  “Chronic hyperglycemia increases pancreatic β-cell metabolic activity, contributing to glucotoxicity-induced β-cell failure and loss of functional β-cell mass, potentially in multiple forms of diabetes.”  […]

Remedi publishes on ATP-sensitive potassium channels in hyperinsulinism and type 2 diabetes

On February 23, Maria S. Remedi, PhD and collaborators had their findings published in “Diabetes,” titled “ATP-Sensitive Potassium Channels in Hyperinsulinism and Type 2 Diabetes: Inconvenient Paradox or New Paradigm?” The article is meant to assess if adenosine triphosphate-sensitive potassium (KATP) channels are a new and effective way of thinking, in regard to hyperinsulinism and type […]