Jiang publishes research on early- and adult-onset forms of Krabbe Disease 

Xuntian Jiang, PhD

In May, Xuntian Jiang, PhD and colleagues had their research titled “CRISPR-Cas9 Knock-In of T513M and G41S Mutations in the Murine β–Galactosyl-Ceramidase Gene Re-capitulates Early-Onset and Adult-Onset Forms of Krabbe Disease,” published in “Frontiers in Molecular Neuroscience.”  Krabbe Disease is a genetic deficiency disorder of the lysosomal enzyme β-galactosyl-ceramidase (GALC). The correlation between reduced activity […]

Jiang publishes research on AAV gene therapy for Tay-Sachs disease

On February 10, Xuntian Jiang, PhD and collaborators had their research titled, “AAV gene therapy for Tay-Sachs disease,” published in “Nature Medicine.”  Tay-Sachs disease (TSD) is defined as an inherited neurological disorder caused by deficiency of hexosaminidase A.   The study assesses two patients with infantile TSD in an adeno-associated virus (AAV) gene therapy expanded-access […]