Xiaochao Wei, PhD, Clay F. Semenkovich, MD and collaborators had their findings published July 3 in Circulation Research. The publication is titled, “Endothelial Palmitoylation Cycling Coordinates Vessel Remodeling in Peripheral Artery Disease.”
Peripheral artery disease, common in metabolic syndrome and diabetes mellitus, responds poorly to medical interventions and is characterized by chronic vessel immaturity leading to lower extremity amputations.
The researchers’ objective in their research was to define the role of reversible palmitoylation at the endothelium in the maintenance of vascular maturity. Palmitoylation coordinates vessel remodeling in peripheral artery disease.
The authors concluded, “These results suggest that endothelial depalmitoylation is regulated by the metabolic milieu and controls plasma membrane partitioning to maintain vascular homeostasis.”
Authors include Sangeeta Adak, Mohamed Zayed, Li Yin, Chu Feng, Sarah L. Speck, Rahul S. Kathayat, Qiang Zhang, and Bryan C. Dickinson.