On September 21, Sina Jasim, MD, in collaboration with Washington University Department of Surgery colleagues Eileen R. Smith, MD; Corbin Frye, MD; T.K. Pandian, MD, MPH; William E. Gillanders, MD; John A. Olson Jr., MD, PhD; and Taylor C. Brown, MD, MHS, FACS, had their research article titled “Molecular characteristics of isthmus papillary thyroid cancers: Supporting evidence for unfavorable clinical behavior,” published by The American Journal of Surgery.
In the article, the authors study the molecular characteristics of isthmus papillary thyroid cancers (PTCs) and hypothesize that they have “a more unfavorable molecular profile.” Dr. Jasim and colleagues perform an analysis by utilizing The Cancer Genome Atlas database to assess the clinical, mutation and gene expression data of isthmus PTCs in comparison to non-isthmus PTCs.
In conclusion, they state that their findings “provide a possible molecular explanation for the more aggressive behavior reported in isthmus PTCs.”
Eileen R. Smith, C. Corbin Frye, T.K. Pandian, William E. Gillanders, John A. Olson, Taylor C. Brown, Sina Jasim. Molecular characteristics of isthmus papillary thyroid cancers: Supporting evidence for unfavorable clinical behavior. The American Journal of Surgery. 2023. ISSN 0002-9610, https://doi.org/10.1016/j.amjsurg.2023.09.005