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Management of adrenocortical carcinoma

Sina Jasim, MD
Sina Jasim, MD

Faculty member Sina Jasim, MD and her collaborator, Mouhammed Amir Habra, M.D. from the University of Texas MD Anderson Cancer Center recently reviewed the current knowledge regarding clinical management of adrenocortical carcinoma (ACC.) Adrenocortical carcinoma is a rare endocrine malignancy typically with poor prognosis.

The authors stated in their findings, “Surgery remains the cornerstone for localized ACC management. In more advanced cases, debulking surgery when feasible can help with hormonal control and may allow the initiation of systemic therapy. Over the last few years, our understanding of ACC molecular pathogenesis has expanded with no significant change in treatment options. Platinum-based chemotherapy is the gold standard in metastatic ACC despite suboptimal efficacy. Tyrosine kinase inhibitor use did not result in meaningful benefit in ACC patients. Multiple clinical trials are currently exploring the role of immunotherapy in ACC. Despite the remarkable improvement in our understanding of the molecular signature and pathways in ACC, this knowledge did not yield a major breakthrough in management of advanced ACC. Multi-institutional and international collaborations are needed to identify promising treatments and new therapeutic targets to improve the care of ACC patients.”

Management of Adrenocortical Carcinoma