Tag: semenkovich

Semenkovich publishes research on the governs of allele-specific expression 

In July, Clay F. Semenkovich, MD and colleagues had their research titled “Genetic, epigenetic, and environmental mechanisms govern allele-specific gene expression,” published in “Genome Research.”  Allele-specific expression (ASE) is when one allele is expressed more than the other. ASE is caused by genetic and epigenic factors that alter the final composition of a gene’s product, […]

Semenkovich publishes research on mechanisms to improve targeted atherosclerosis therapy 

On June 15, Clay F. Semenkovich, MD and collaborators had their research titled “Altered Peroxisome Proliferator-Activated Receptor Alpha Signaling in Variably Diseased Peripheral Arterial Segments,” published in “Frontiers in Cardiovascular Medicine.”  “Peripheral atherosclerosis that accumulates in the extracranial carotid and lower extremity arteries can lead to significant morbidity and mortality. However, atherosclerotic disease progression is […]

Wei and Semenkovich publish research presenting an anti-viral strategy against COVID-19 

In April, Xiaochao Wei, PhD, Clay F. Semenkovich, MD and colleagues had their research titled “Suppressing fatty acid synthase by type I interferon and chemical inhibitors as a broad spectrum anti-viral strategy against SARS-CoV-2,” published in “Acta Pharmaceutica Sinica B.”  SARS-VoC-2, otherwise known as COVID-19, is an “emerging viral pathogen and a major global public […]

Semenkovich publishes research on how parent-of-origin effects shape metabolic traits

Clay F. Semenkovich, MD

In March, Clay F. Semenkovich, MD and colleagues had their work titled “Parent-of-origin effects propagate through networks to shape metabolic traits,” published in “eLife.”  Parent-of-origin effects (POE) are a class of genetic effects transmitted from parents to their offspring and are “unexpectedly common in complex traits, including metabolic and neurological traits.” Environmental factors can modify […]

Semenkovich and Rajagopal publish article on ‘fatty retina’ linking to vision loss in diabetes

Clay F. Semenkovich, MD and Rithwick Rajagopal, MD, PhD recently published an article in Lipid Maps titled, “’Fatty retina’ – A root cause of vision loss in diabetes?”  “Diabetes is a disease of broadly disordered metabolism that affects how cells handle lipids, amino acids and signaling networks that regulate growth and proliferation, in addition to […]