In July, Clay F. Semenkovich, MD and colleagues had their research titled “Genetic, epigenetic, and environmental mechanisms govern allele-specific gene expression,” published in “Genome Research.”
Allele-specific expression (ASE) is when one allele is expressed more than the other. ASE is caused by genetic and epigenic factors that alter the final composition of a gene’s product, “leading to expression imbalances that can have functional consequences on phenotypes.”
However, the impact of environmental signals on ASE is understudied.
In this study, Semenkovich and collaborators provide insight to how “how genetic, epigenetic, and environmental mechanisms govern allele-specific expression, which is an essential step toward deciphering the genotype-to-phenotype map.”
Genetic, epigenetic, and environmental mechanisms govern allele-specific gene expression