In December, Clair Crewe, PhD and colleagues had their research titled “Deficient Caveolin-1 Synthesis in Adipocytes Stimulates Systemic Insulin-Independent Glucose Uptake via Extracellular Vesicles,” published in “Diabetes.”
Within plasma membrane invaginations, is an essential structural and signaling component called cavelolin-1 (cav1). It is also abundantly found in adipocytes. Throughout the study, Crewe and collaborators analyze the relationship between cav1 and insulin-independent glucose.
In gathering various data, they conclude that “ad-cav1 is essential for healthy adaptation of the adipose tissue to overnutrition and prevents aberrant propagation of neg-ative phenotypes to other organs by extracellular vesicles.”