On March 9, Adriana S. Dusso, PhD and colleagues had their work titled “Role of Klotho and AGE/RAGE-Wnt/β-Catenin Signalling Pathway on the Development of Cardiac and Renal Fibrosis in Diabetes,” published in the International Journal of Molecular Sciences.
A key influence on the development of long-term diabetic complications, including cardiac and renal dysfunction, is fibrosis.
The authors performed an experimental study in a long-term rat model that resembled type 1 diabetes metllitus to “investigate the role of soluble Klotho (sKlotho), advanced glycation end products (AGEs)/receptor for AGEs (RAGE), fibrotic Wnt/β-catenin pathway, and pro-fibrotic pathways in kidney and heart.”
In their findings, the authors show intriguing insights into the distinct roles that they play in the progression of renal and cardiac fibrosis, highlighting that “ increases in urinary sKlotho and sRAGE excretion due to polyuria in the diabetic rats may serve as early biomarkers of their reduction in circulation.”
Martín-Carro, B., Martín-Vírgala, J., Fernández-Villabrille, S., Fernández-Fernández, A., Pérez-Basterrechea, M., Navarro-González, J. F., Donate-Correa, J., Mora-Fernández, C., Dusso, A. S., Carrillo-López, N., Panizo, S., Naves-Díaz, M., Fernández-Martín, J. L., Cannata-Andía, J. B., & Alonso-Montes, C. (2023). Role of Klotho and AGE/RAGE-Wnt/β-Catenin Signalling Pathway on the Development of Cardiac and Renal Fibrosis in Diabetes. International Journal of Molecular Sciences, 24(6), 5241. https://doi.org/10.3390/ijms24065241