Urano and Jasim discuss Wolfram syndrome case report on AACE Podcast 

On September 11, 2023, Fumihiko Urano, MD, PhD and Sina Jasim, MD, MPH, were featured on the AACE’s podcast titled “Episode 41: AACE Clinical Case Report on Wolfram Syndrome.” As the editor in chief of AACE Clinical Case Reports, Dr. Jasim welcomes Wolfram syndrome expert Dr. Urano, to discuss his recent case report, published by […]

Associations of HNF1β gene deletion

On September 6, 2023, Sister Grace Miriam Usala, MS, MD; Alberto Sobrero, BSc; Amy Riek, MD; Janet B. McGill, MD, MA, FACE, FACP and Fumihiko Urano, MD, PhD had their clinical case report titled “Cystic and Atrophic Kidneys, Atrophic Pancreas, Arcuate Uterus, and Diabetes Mellitus Associated With Deletion of HNF1β Gene,” published in AACE Clinical […]

Brown, Urano and colleagues publish an article on a potential treatment for human, preclinical Wolfram syndrome cases 

On March 30, Cris Brown, BA and Fumihiko Urano, MD, PhD of Urano Lab, alongside colleagues from Belgique, Belgium and Italy, had their article titled “GLP-1R agonists demonstrate potential to treat Wolfram syndrome in human preclinical models,” published in Diabetologia.  Wolfram syndrome is a rare autosomal recessive disorder that commonly manifests itself in the form […]

Protein palmitoylation helps to model the evolution of some forms of type 2 diabetes   

On February 7, Guifang Dong, PhD; Sangeeta Adak, PhD; Qiang Zhang, PhD; Chu Feng, MS; Li Yin, MD; Sarah Speck; Shuntaro Morikawa; Rie Asada, PhD; Fumihiko Urano, MD, PhD; Maria Remedi, PhD; Xiaochao Wei, PhD; Clay Semenkovich, MD; and collaborators had their work published in “Cell Metabolism.”  “Hyperinsulinemia often precedes type 2 diabetes,” and palmitoylation, […]

Urano featured in PBS Wolfram syndrome documentary 

In April, Fumihiko Urano, MD, PhD was featured in the documentary “Colorado Voices: Ellie White,” to raise awareness of the rare genetic disorder, Wolfram syndrome. The short documentary was published by Rocky Mountain PBS and tells the story of Colorado college student Ellie White, who lives with the disorder. Although the disorder is very rare […]

Urano Lab receives funding to test the efficacy of a Sigma 1 receptor agonist pridopidine

Fumihuko Urano, MD, PhD

The Snow Foundation, the Ellie White Foundation, and the Unravel Wolfram Syndrome have donated funds to the research lab of Fumihiko Urano, MD, PhD. The research team will use the funds to test the efficacy of a Sigma 1 receptor agonist, pridopidine, developed by Prilenia in pre-clinical models of Wolfram syndrome. Successful completion of this […]

Semenkovich Lab and collaborators show the evolution of type 2 diabetes through APT1 deficiency 

On January 11, Semenkovich Lab and collaborators, had their research titled “Palmitoylation couples insulin hypersecretion with β cell failure in diabetes,” published in “Cell Metabolism.”  Hyperinsulinemia is known to often come before type 2 diabetes. In the study, they explain how acyl-protein thioesterase 1 (APT1) knockdown in nondiabetic islets causes insulin hypersecretion.  By using palmitoylation proteomics, their […]

Millman and Urano publish research on patient iPSC-derived disease models 

On September 22, Jeffrey R. Millman, PhD and Fumihiko Urano, MD, PhD, along with colleagues, had their research titled, “Multidimensional analysis and therapeutic development using patient iPSC–derived disease models of Wolfram syndrome,” published in “JCI Insight.”  “Wolfram syndrome is a rare genetic disorder largely caused by pathogenic variants in the WFS1 gene and manifested by diabetes mellitus, […]