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Crewe publishes research on the effects of adipocyte mesenchymal transition on mammary tumors 

On September 13, 2022, Clair Crewe, PhD and colleagues had their work titled “Adipocyte mesenchymal transition contributes to mammary tumor progression,” published in “Cell Reports.” 

“Obesity is associated with increased cancer incidence and progression.” There is a need for more research in understanding the mechanistic relationship between adiposity and cancer. 

In the study, Crewe and collaborators study this mechanistic relationship, finding that “the metabolic interplay between tumor cells and adipocytes induces adipocyte mesenchymal transition and contributes to reconfigure the stroma into a more tumor-friendly microenvironment.” 

Adipocyte mesenchymal transition contributes to mammary tumor progression