Dr. Jeffrey Millman, Professor of Medicine in the Division of Endocrinology, Metabolism and Lipid Research at Washington University School of Medicine, has co-authored a landmark review article on the heterogeneity of type 1 diabetes (T1D), published simultaneously on July 30 in three leading journals: Diabetologia, Diabetes, and Diabetes Care. This rare triple-publication, titled “The Heterogeneity […]
A groundbreaking clinical trial utilizing technology developed previously by Jeffrey R. Millman, PhD has reported promising new findings in the treatment of type 1 diabetes (T1D). The study, conducted by Vertex Pharmaceuticals, evaluated a stem cell-derived islet (SC-islet) replacement therapy known as Zimislecel. In this Phase 1/2 trial, researchers implanted SC-islets into patients with T1D […]
On March 5, Jeffrey Millman, PhD was featured on The Sugar Science’s Ask the Expert webinar series, hosted on YouTube. The episode was titled “Unraveling Cellular Complexity in Stem Cell-Derived Islet Identity through Single-Cell Sequencing.” In the webinar, Dr. Millman gave an overview of using stem cell-derived islets in diabetes cellular therapy, and a comparative […]
On May 8, Nathaniel Hogrebe, PhD; Jeffrey Millman, PhD; and collaborators published the research article “Hypoimmune induced pluripotent stem cells survive long term in fully immunocompetent, allogeneic rhesus macaques” in Nature Biotechnology demonstrating that immune-engineered induced pluripotent stem cells (iPSCs) can survive long-term without provoking an immune reaction. These hypoimmune iPSCs were engineered to lack the […]
Dr. Jeffrey Millman has received a renewal of his NIH R01 grant titled “Studying the Role of the Microenvironment on Differentiation and Maturation of Beta Cells”, providing 4 years of additional support into his research. Human pluripotent stem cells (hPSCs) hold great potential as a renewable source of insulin-producing islets for diabetes treatment. While transplantation […]
In prioritization of environmental sustainability in their workspace, Millman Lab recently joined the Washington University Green Labs Program, certifying at level Gold! The lab’s sustainability initiatives are led by current lab member and Green Lab Representative, Erika Brown. Most recently, Millman Lab volunteered at the O’Fallon Park Clean-Up and Family Fun Day, in honor of […]
In January, Jeffrey Millman, PhD was awarded funding of $450,000 from JDRF for his lab’s project titled “Genetic Engineering to Improve Engraftment of Stem Cell-Derived Islets.” Transplantation of new insulin-producing cells into the patients could be a functional cure for type 1 diabetes. We have developed a method for creating these cells in the lab […]
In 2022, Jeffrey R. Millman, PhD and collaborators had their work titled “A Predictive Oxygen Durability Model to Analyze Oxygen Consumption of Insulin Producing Cells Encapsulated Within a Highly Oxygenated Hydrogel,” published in “Advanced Materials Technologies.” In the study, they compare model estimations and experimental results, demonstrating that application of this mathematical model on predictive […]
On September 22, Jeffrey R. Millman, PhD and Fumihiko Urano, MD, PhD, along with colleagues, had their research titled, “Multidimensional analysis and therapeutic development using patient iPSC–derived disease models of Wolfram syndrome,” published in “JCI Insight.” “Wolfram syndrome is a rare genetic disorder largely caused by pathogenic variants in the WFS1 gene and manifested by diabetes mellitus, […]