On March 5, Jeffrey Millman, PhD was featured on The Sugar Science’s Ask the Expert webinar series, hosted on YouTube. The episode was titled “Unraveling Cellular Complexity in Stem Cell-Derived Islet Identity through Single-Cell Sequencing.” In the webinar, Dr. Millman gave an overview of using stem cell-derived islets in diabetes cellular therapy, and a comparative […]
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Hogrebe and Millman contribute to new study on immune-engineered stem cells
On May 8, Nathaniel Hogrebe, PhD; Jeffrey Millman, PhD; and collaborators published the research article “Hypoimmune induced pluripotent stem cells survive long term in fully immunocompetent, allogeneic rhesus macaques” in Nature Biotechnology demonstrating that immune-engineered induced pluripotent stem cells (iPSCs) can survive long-term without provoking an immune reaction. These hypoimmune iPSCs were engineered to lack the […]
Millman receives grant renewal to advance diabetes cell replacement therapy and disease modeling
Dr. Jeffrey Millman has received a renewal of his NIH R01 grant titled “Studying the Role of the Microenvironment on Differentiation and Maturation of Beta Cells”, providing 4 years of additional support into his research. Human pluripotent stem cells (hPSCs) hold great potential as a renewable source of insulin-producing islets for diabetes treatment. While transplantation […]
Millman Lab receives level Gold certification for environmental sustainability
In prioritization of environmental sustainability in their workspace, Millman Lab recently joined the Washington University Green Labs Program, certifying at level Gold! The lab’s sustainability initiatives are led by current lab member and Green Lab Representative, Erika Brown. Most recently, Millman Lab volunteered at the O’Fallon Park Clean-Up and Family Fun Day, in honor of […]
Findings may lead to improved insulin-secreting cells derived from stem cells (Links to an external site)
Millman Lab receives funding to improve engraftment of stem cells through genetic engineering
In January, Jeffrey Millman, PhD was awarded funding of $450,000 from JDRF for his lab’s project titled “Genetic Engineering to Improve Engraftment of Stem Cell-Derived Islets.” Transplantation of new insulin-producing cells into the patients could be a functional cure for type 1 diabetes. We have developed a method for creating these cells in the lab […]
Millman publishes research on an oxygen durability model for insulin producing cells
In 2022, Jeffrey R. Millman, PhD and collaborators had their work titled “A Predictive Oxygen Durability Model to Analyze Oxygen Consumption of Insulin Producing Cells Encapsulated Within a Highly Oxygenated Hydrogel,” published in “Advanced Materials Technologies.” In the study, they compare model estimations and experimental results, demonstrating that application of this mathematical model on predictive […]
Millman and Urano publish research on patient iPSC-derived disease models
On September 22, Jeffrey R. Millman, PhD and Fumihiko Urano, MD, PhD, along with colleagues, had their research titled, “Multidimensional analysis and therapeutic development using patient iPSC–derived disease models of Wolfram syndrome,” published in “JCI Insight.” “Wolfram syndrome is a rare genetic disorder largely caused by pathogenic variants in the WFS1 gene and manifested by diabetes mellitus, […]
Millman featured in AP News: Do stem cells grow better in space?
On July 17, Jeffrey R. Millman, PhD was featured in AP News’ article titled, “High-flying experiment: Do stem cells grow better in space?” As scientists see great promise in stem cell research, “researcher Dhruv Sareen’s own stem cells are now orbiting the Earth. The mission? To test whether they’ll grow better in zero gravity.” […]
Millman publishes research on insulin-producing SC-islets after transplantation
On March 16, Jeffrey R. Millman, PhD and collaborators had their research titled “Differential Function and Maturation of Human Stem Cell-Derived Islets After Transplantation,” published in issue 3 of “Stem Cells Translational Medicine.” It is evident that cell replacement therapy is a potential treatment for patients with diabetes. One possible renewable source of replacement cells are stem-cell […]