The mass spectrometry core provides a variety of services that include high resolution mass measurement of ESI ionizable compounds; comprehensive lipid analysis; MALDI-TOF low resolution measurements of proteins, peptides, oligosaccharides; targeted drug/metabolite/lipid quantitation via triple quad and Q-tof; GC-MS of targeted biomolecules such as 19 canonical amino acids, TCA cycle metabolites, sterols and other volatile or derivatizable compounds; stable isotope tracer analysis of amino acids and TCA cycle metabolites; limited metabolomic analysis with GC-MS amenable metabolites in NIST EI library and statistical analysis via GraphPad Prizm.

MALDI plate



Menu of services are offered to Institute of Clinical and Translational Sciences members.

  • High resolution accurate mass measurement (Orbitrap/FT MS) of any compounds ionizable by ESI, including synthetic compounds, protein/peptides, lipid/glycolipid/peptidolipids, drugs, etc, to a mass accuracy within 3 ppm deviation.
  • Routine loop injection/LC mass spectrometric analysis (TSQ and Q-TOF) for targeted compound such as drug/metabolite quantitation, non-targeted/unknown structure analysis, lipid/metabolite profiling.
  • Fast MALDI-TOF mass measurements of peptides, proteins, oligosaccharides, DNA/RNA, polymers and other large molecules that are less suitable for ESI/MS analysis. Limited TOF/TOF can be arranged through consulation.
  • Head-space GC/MS analysis of gas, and other volatile molecules
  • Stable isotope tracer GC-MS quantitative analysis of targeted amino acids (>19 a.a), TCA cycle metabolites, cholesterol/ergosterol, etc..
  • GC/MS analysis of fatty acids, drugs, steroids, small sugar/oligosaccharides and other small molecules
  • Limited metabolomic analysis with GC-MS amenable metabolites via Agilent software MPP and metaboanalyst


Biomedical Mass Spectrometry Laboratory (8th Floor Southwest Tower) Fee-for-Service (Effective Aug. 1, 2021)

Instrumentation-Service-Analysis ProvidedAcademic Collaborator /CNRU/DRTC MembersAcademic Non-CollaboratorNon-Academic
MS staff conducts the analysis-operates the instrument$65$100$300
PI/Technician conducts the analysis-operates the instrument$45$65$300
MS staff conducts the analysis-operates the instrument$65$100$300
PI/Technician conducts the analysis-operates the instrument$45$65$300
High resolution (accurate) mass measurement$65/Sample$65/Sample$250/Sample
Sample preparation support-advice-MS interpretation$65
Training (instrument operation, sample prep, data analysis, database searching)$65
Provision of specialized MS-related service (repairs, maintenance)$150

1. All rates are per hour unless otherwise specified. 2. Collaborator is defined as co-authorship for mass spectrometry staff on any abstract, preliminary report, manuscript, patent application that incorporates analytical results generatd using mass spectrometry instrumentation or service provided. 3. When composing budget requests for new grant applications, the PI should contact MS resource Director (Dr. Fong-Fu Hsu; Tel:314-362-0056). The new grant application budget requests for new grant application should include effort for MS staff, MS instrumentation maintenance, service, repair, parts, and consuamable supplies that are based on the anticipated amount of technical support and analytical work required. The director will help the PI compose the budget request, budget item justification, and letter of support or collaboration.


The Biomedical Mass Spectrometry Lab is located at Washington University School of Medicine, on the 8th floor of the Southwest Tower, St. Louis, MO 63110.

WashU School of Medicine Map

Contact Us

Fong-Fu Hsu, PhD
Research Professor of Medicine
Phone: 314-362-0056

Cheryl Frankfater, PhD
Staff Scientist