Muegge Lab

Our lab studies the intestinal endocrine system with the goal of finding new treatments for metabolic and intestinal diseases. Enteroendocrine cells (EECs) in the intestine make more than 20 different hormones, but this system isn’t well understood because the cells are rare, diverse, and historically hard to grow in the lab. We developed a new experimental model that overcomes this barrier to culture and study EECs from primary mouse and human intestinal stem cells. We are using these models to understand the transcriptional and epigenetic control of intestinal and EEC development in health and metabolic disease. Our research team merges techniques from developmental biology, genomics, and systems biology in a highly interdisciplinary, collaborative, and supportive environment.

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