On November 11, Sina Jasim, MD, MPH; Allan Golding, MD; David Bimston, MD; Yang Chen, PhD; Ruochen Jiang, PhD; Yangyang Hao, PhD; Jing Huang, PhD; Joshua P. Klopper, MD; Richard T. Kloos, MD; and Taylor C. Brown, MD, MHS had their research article titled “Cytologic and Molecular Assessment of Isthmus Thyroid Nodules and Carcinomas,” published online ahead of print in the journal Thyroid.
With isthmic thyroid nodules having a higher likelihood of being malignant, and isthmic differentiated thyroid cancer exhibiting less favorable characteristics in comparison to lobar locations, the study aimed to further understand the molecular differences of isthmus thyroid nodules and carcinomas in relevance to the lobes.
In their research, Dr. Jasim and colleagues found indications that “isthmic nodules are more likely to have malignant cytology and increased rates of higher risk molecular alterations compared with lobar nodules,” and that IF-PTC, an infiltrative follicular subtype of PTC, is molecularly unique in contrast to IF-PTC from the lobes. Furthermore, they conclude that additional data is needed to understand if modifications to surgical therapy is warranted in isthmic thyroid cancers relative to lobar cancers, and if the molecular data should influence the management and observance of isthmic thyroid cancer.
Jasim, S., Golding, A., Bimston, D., Alshalalfa, M., Chen, Y., Jiang, R., Hao, Y., Huang, J., Klopper, J. P., Kloos, R. T., & Brown, T. C. (2024). Cytologic and molecular assessment of isthmus thyroid nodules and carcinomas. Thyroid, 34(11). https://doi.org/10.1089/thy.2024.0254