Tag: fumihiko urano

Semenkovich Lab and collaborators show the evolution of type 2 diabetes through APT1 deficiency 

On January 11, Semenkovich Lab and collaborators, had their research titled “Palmitoylation couples insulin hypersecretion with β cell failure in diabetes,” published in “Cell Metabolism.”  Hyperinsulinemia is known to often come before type 2 diabetes. In the study, they explain how acyl-protein thioesterase 1 (APT1) knockdown in nondiabetic islets causes insulin hypersecretion.  By using palmitoylation proteomics, their […]

Millman and Urano publish research on patient iPSC-derived disease models 

On September 22, Jeffrey R. Millman, PhD and Fumihiko Urano, MD, PhD, along with colleagues, had their research titled, “Multidimensional analysis and therapeutic development using patient iPSC–derived disease models of Wolfram syndrome,” published in “JCI Insight.”  “Wolfram syndrome is a rare genetic disorder largely caused by pathogenic variants in the WFS1 gene and manifested by diabetes mellitus, […]

Urano publishes research on elevated plasma neurofilament light chain levels in patients with Wolfram Syndrome 

Fumihuko Urano, MD, PhD

On April 12, Fumihiko Urano, MD, PhD and colleagues had their research titled, “Plasma Neurofilament Light Chain Levels Are Elevated in Children and Young Adults With Wolfram Syndrome,” published in “Frontiers in Neuroscience.”  “Wolfram syndrome is a rare disease caused by pathogenic variants in the WFS1 gene with progressive neurodegeneration. As an easily accessible biomarker […]