In October of 2023, Jennifer Powers Carson, PhD and colleague, Jyoti Arora, MS of the Washington University School of Medicine, Center for Biostatistics and Data Science, had their work published by Clinical Biochemistry. The article was titled, “Glycated serum proteins and albumin but not glycated albumin show negative correlation with BMI in an overweight/obese, diabetic population from the United States.”
Many studies have been done with a narrow range of BMI, showing negative correlations between BMI and glycated albumin (GA). In this article, to better interpret GA levels in obese populations, Dr. Powers Carson and Arora look for trends throughout a wider range of BMIs.
In their analysis, they found that “negative correlations between BMI and albumin or BMI and glycated serum proteins persist in diabetic populations that are obese and overweight, even when a statistically significant negative correlation is not observed between BMI and GA.” They further suggest that a potential contributor of these negative correlations could be inflammation or insulin-mediated changes in protein synthesis, including BMI-related changes to the glomerulus, which “could also affect clearance of albumin or glycated proteins and should be examined.”
Jennifer Powers Carson, Jyoti Arora. Glycated serum proteins and albumin but not glycated albumin show negative correlation with BMI in an overweight/obese, diabetic population from the United States. Clinical Biochemistry. Volume 120. 2023. 110654. ISSN 0009-9120. https://doi.org/10.1016/j.clinbiochem.2023.110654